Clinical and paraclinical aspects in Cushing syndrome (hyperadrenocorticism) in dogs.

摘要: The common clinical aspects of the Cushing (hyperadrenocorticism) syndrome were: symmetrical alopecia, shineless fur, thin skin with reduced elasticity, abdominal ptosis, hyperpigmentation skin, cutaneous calcification and muscular atrophy. Polydipsia, polyuria sometimes polyphagia were also noted. biochemical profile revealed moderate hypercortisolemia (50.8±13.5), hyperglycemia (143.4±3.3 mg/dl), hypercholesterolemia (332.0±2.9 higher serum activity hepatic transaminases (AST=89,72±2,3 UI/L, ALT=93.26±2.6 UI/L) alkaline phosphatase (378.0±3.8 UI/L). high levels phosphatase, associated some signs, represent an important element in establishing paraclinical diagnosis hyperadrenocorticism syndrome. echography hypertrophy adrenal glands (2.92x1.43 cm), necropsy showed diffuse calcifications glands, hepatomegaly splenic hematoma, all being a consequence glucocorticoids excess. In dogs syndrome, histological lesions metabolically active cells (large, intensely stained big nuclei), lipid inclusions, precursors glucocorticoid hormones, inactive (small, dark stained, picnotic nuclei or rich heterochromatin).