Expression array analysis of the hepatocyte growth factor invasive program

作者: Fabiola Cecchi , Chih-Jian Lih , Young H. Lee , William Walsh , Daniel C. Rabe

DOI: 10.1007/S10585-015-9735-0

关键词:

摘要: Signaling by human hepatocyte growth factor (hHGF) via its cell surface receptor (MET) drives mitogenesis, motogenesis and morphogenesis in a wide spectrum of target types embryologic, developmental homeostatic contexts. Oncogenic pathway activation also contributes to tumorigenesis cancer progression, including tumor angiogenesis metastasis, several prevalent malignancies. The HGF gene encodes full-length hHGF two truncated isoforms known as NK1 NK2. induces all three activities at modestly reduced potency, whereas NK2 stimulates only enhances HGF-driven metastasis transgenic mice. Prior studies have shown that mouse (mHGF) binds with high affinity MET. Here we show that, like NK2, mHGF motility, invasion spontaneous PC3M prostate adenocarcinoma cells mice through To identify genes signaling pathways associated motogenic metastatic signaling, i.e., the invasive program, expression profiling was performed using treated hHGF, or mHGF. Results obtained Ingenuity Pathway Analysis software showed significant overlap networks involved movement metastasis. Interrogating Cancer Genome Atlas project identified subset 23 changes strong tendency for co-occurrence patients were significantly decreased disease-free survival.

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