The adverse outcome pathway for skin sensitisation: Moving closer to replacing animal testing.
作者： Terry W. Schultz , Gergana Dimitrova , Sabcho Dimitrov , Ovanes G. Mekenyan
DOI: 10.1177/026119291604400515
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摘要: This article outlines the work of Organisation for Economic Co-operation and Development (OECD) that led to being jointly awarded 2015 Lush Black Box Prize. The award-winning centred on development 'The Adverse Outcome Pathway Skin Sensitisation Initiated by Covalent Binding Proteins'. (AOP) has provided mechanistic basis integration skin sensitisation-related information. Recent developments in integrated approaches testing assessment, based AOP, are summarised. impact AOP regulatory policy Three Rs discussed. An overview next generation sensitisation module OECD QSAR Toolbox, more-recent at Laboratory Mathematical Chemistry, is also presented.
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