Early Lesions of the Human Mammary Gland and their Relationship to Precancerous Lesions of Other Species

摘要: Preneoplastic pathological lesions are tissue formations possessing an increased probability of developing neoplasia in comparison to the that corresponding type neoplasm will develop adjacent morphologically normal tissue. Lesions with presumed preneoplastic potential have been described mammary glands mice, rats, dogs, subhuman primates, and humans. In every instance stand out from background as focal, multicentric, hyperplastic. The epithelial cells variable degrees so-called premalignant atypia (anaplasia), on this basis can be arranged arbitrary morphological continuum linking pre-invasive carcinoma. mice there is direct experimental proof more cancers arise precancerous than human, however, techniques for such observation not yet perfected assignment risk particular focal human breast basea statistical inference.