ApoE4 Allele Is Associated With Late-Life Depression: A Population-Based Study
作者： Yung-Chieh Yen , George W. Rebok , Joseph J. Gallo , Ming-Jen Yang , For-Wey Lung
DOI: 10.1097/JGP.0B013E3180F63373
关键词:
摘要: Objective This study aimed to clarify the relationship between ɛ4 allele and late-life depression, taking into account lipid profile, vascular diseases, sociodemographics. Methods Using a multilevel stratified random sampling strategy, total of 500 subjects aged 65 74 years were recruited for this cross-sectional from official household records an entire county in southern Taiwan. Depressive symptoms assessed by Taiwanese Depression Questionnaire (TDQ). Cognitive function was Short Portable Mental Status Questionnaire. Blood samples collected determination apolipoprotein E (ApoE) polymorphism profile. Results A 283 (58.7% male, with mean age 69.2 ± 2.7 years) completed all questionnaires collection blood samples. χ 2 test, overall difference frequency presence significant among severe group (TDQ score >18), moderate 9–18), mild Conclusion The ApoE may be correlated depression elderly through ways other than "vascular depression" hypothesis.
elsevier.com
sci-hub.se 参考文章(88)
George S. Zubenko, Richelle Henderson, J. Scott Stiffler, Stacy Stabler, Jules Rosen, Barry B. Kaplan, Association of the APOE ε4 allele with clinical subtypes of late life depression Biological Psychiatry. ,vol. 40, pp. 1008- 1016 ,(1996) , 10.1016/S0006-3223(96)00046-7
Anne-Sophie Rigaud, Latchezar Traykov, Ludovica Caputo, Joël Coste, Florence Latour, Rémy Couderc, Florence Moulin, François Boller, Françoise Forette, Association of the Apolipoprotein E ε4 Allele with Late-Onset Depression Neuroepidemiology. ,vol. 20, pp. 268- 272 ,(2001) , 10.1159/000054801
Carl DeLuca, James R. Barnard, Giso Feussner, Ernst J. Schaefer, Ilona A. Larson, Jose M. Ordovas, Association of apolipoprotein (Apo)E genotype with plasma apo E levels. Atherosclerosis. ,vol. 148, pp. 327- 335 ,(2000) , 10.1016/S0021-9150(99)00280-4
Jorge Cervilla, Martin Prince, Suzanne Joels, Carsten Russ, Simon Lovestone, Genes Related to Vascular Disease (APOE, VLDL-R, DCP-1) and Other Vascular Factors in Late-Life Depression The American Journal of Geriatric Psychiatry. ,vol. 12, pp. 202- 210 ,(2004) , 10.1097/00019442-200403000-00011
G. UTERMANN, M. HEES, A. STEINMETZ, Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man. Nature. ,vol. 269, pp. 604- 607 ,(1977) , 10.1038/269604A0
J R Nesselroade, Robert Plomin, M Gatz, G E McClearn, N L Pedersen, Importance of shared genes and shared environments for symptoms of depression in older adults Journal of Abnormal Psychology. ,vol. 101, pp. 701- 708 ,(1992) , 10.1037//0021-843X.101.4.701
Yung-Chieh Yen, Ming-Jen Yang, Chun-Hua Shih, For-Wey Lung, Cognitive impairment and associated risk factors among aged community members International Journal of Geriatric Psychiatry. ,vol. 19, pp. 564- 569 ,(2004) , 10.1002/GPS.1131
G Lindberg, G Larsson, S Setterlind, L Rastam, Serum lipids and mood in working men and women in Sweden. Journal of Epidemiology and Community Health. ,vol. 48, pp. 360- 363 ,(1994) , 10.1136/JECH.48.4.360
PhilipR. Wenham, WilliamH. Price, Gillian Blundell, Apolipoprotein E genotyping by one-stage PCR. The Lancet. ,vol. 337, pp. 1158- 1159 ,(1991) , 10.1016/0140-6736(91)92823-K
K. Ranga Rama Krishnan, Larry A. Tupler, James C. Ritchie, William M. McDonald, David L. Knight, Charles B. Nemeroff, Bernard J. Carroll, Apolipoprotein E-ε4 frequency in geriatric depression Biological Psychiatry. ,vol. 40, pp. 69- 71 ,(1996) , 10.1016/0006-3223(95)00424-6