Vinorelbine (Navelbine): a third-generation vinca alkaloid.

摘要: The vinca alkaloids represent one of the oldest classes antineoplastic agents used in humans with a wide spectrum activity against both animal and human tumors. These are known to inhibit microtubule polymerization. Vinorelbine is semisynthetic analog that reached Clinical Trial on basis less preclinical evidence toxicity neuronal tissue greater cytotoxic models than older compounds this class. In humans, clearance agent shows variation among subjects predominant being hematological. Significant antitumor has been observed diseases previously have shown respond alkaloids.