Androgen blocks apoptosis of hormone-dependent prostate cancer cells.

作者: Cai Bowen , Kotohiko Kimura , Mark Markowski , Edward P. Gelmann

DOI:

关键词:

摘要: Androgen plays a critical role in the promotion and growth of prostate cancer. Androgen ablation has an expanding role in prostate cancer treatment and is now used to improve the …

参考文章(54)
J. F. R. Kerr, J. Searle, Deletion of cells by apoptosis during castration-induced involution of the rat prostate. Virchows Archiv B Cell Pathology. ,vol. 13, pp. 87- 102 ,(1973) , 10.1007/BF02889300
P. Stattin, P. Westin, A. Bergh, J. E. Damber, Castration therapy rapidly induces apoptosis in a minority and decreases cell proliferation in a majority of human prostatic tumors. American Journal of Pathology. ,vol. 146, pp. 1368- 1375 ,(1995)
Martin Reers, Stephen T. Smiley, Cristina Mottola-Hartshorn, Ann Chen, Mei Lin, Lan Bo Chen, Mitochondrial membrane potential monitored by JC-1 dye. Methods in Enzymology. ,vol. 260, pp. 406- 417 ,(1995) , 10.1016/0076-6879(95)60154-6
Sheldon Milstien, Victor E. Nava, Sarah Spiegel, Kotohiko Kimura, Lisa C. Edsall, Olivier Cuvillier, Edward P. Gelmann, Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells. Cancer Research. ,vol. 60, pp. 4468- 4474 ,(2000)
Trapman J, Vlietstra Rj, Hermans Kg, van Steenbrugge Gj, van Alewijk Dc, Frequent Inactivation of PTEN in Prostate Cancer Cell Lines and Xenografts Cancer Research. ,vol. 58, pp. 2720- 2723 ,(1998)
John T. Isaacs, Hugh F. English, Natasha Kyprianou, Programmed cell death during regression of PC-82 human prostate cancer following androgen ablation. Cancer Research. ,vol. 50, pp. 3748- 3753 ,(1990)
Osman Nidai Ozes, Lindsey D Mayo, Jason A Gustin, Susan R Pfeffer, Lawrence M Pfeffer, David B Donner, None, NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase Nature. ,vol. 401, pp. 82- 85 ,(1999) , 10.1038/43466
Christa Miliaresis, Christa Miliaresis, Nicholas Tonks, Nicholas Tonks, Ramon Parsons, Ramon Parsons, Laura Simpson, Laura Simpson, Michael P. Myers, Michael P. Myers, Jing Li, Jing Li, Michelle Takahashi, Michelle Takahashi, The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene. Cancer Research. ,vol. 58, pp. 5667- 5672 ,(1998)