Association of K121Q polymorphism in ENPP1 (PC-1) with BMI in Caucasian and African-American adults.
作者： N Matsuoka , A Patki , H K Tiwari , D B Allison , S B Johnson
关键词:
摘要: To test for association of the ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) K121Q polymorphism with body mass index (BMI) and diabetes in a large sample Caucasians African-Americans by selectively genotyping individuals at extremes phenotypic distribution. Subsets comprising BMI distribution (10th–20th above 90th percentile between 10th–30th 80th African-Americans) from group 10 260 Caucasian 2268 African-American adults participating New York Cancer Project were studied. Subjects genotyped ENPP1 pyrosequencing tested regression analysis. Regression analysis as dependent variable demonstrated significant (P=0.02) genotype BMI, no race-by-genotype interaction (P=0.30). Compared Q/Q or Q/K individuals, K/K had approximately 1.3 kg/m2 higher, without effects age, gender race. By logistic analysis, alleles effect on status (P=0.37) obese subjects. In both African-Americans, K121 was associated increased but not diabetes.
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