Ta@Ag Porous Array with High Stability and Biocompatibility for SERS Sensing of Bacteria.

摘要: The reliable sensing of bacteria by surface-enhanced Raman scattering (SERS) technology necessitates a rational design substrate with high sensitivity, stability, and minimal invasion. Hence, bimetallic Ta@Ag film porous array is developed the magnetron sputtering technique structure could be controlled Ta dopant. A connected ligaments compact granular nanoprotrusions fascinating for SERS sensing. It makes steady signals even in harsh chemical environments due to its structural stability. configuration binary has higher surface free energy than that pure Ag, strong bactericidal activity Ag suppressed efficiently. Using E. coli as model pathogen, maintain long-term survival rate up 95% limit detection down 102 CFU/mL, which measured standard colony-counting method. In sum, this work provides promising strategy fabricate corrosion-resistant biocompatible microbial cells.