TGF-β has paradoxical and context dependent effects on proliferation and anoikis in human colorectal cancer cell lines
作者： Nina M. Muñoz , Ji Yeon Baek , William M. Grady
DOI: 10.1080/08977190802291667
关键词:
摘要: Transforming growth factor-beta (TGF-beta) is a pluripotent cytokine that can have both tumor suppressing and promoting effects on epithelial cells. It unclear what determines when TGF-beta its signaling pathway act predominantly as suppressor or tumor-promoter whether classes of concurrently cell. We investigated the effect anoikis in colorectal cancer cell lines sensitive to TGF-beta-mediated inhibition determine if context cells could be one factors would affect exerts oncogene activity colon observed variable these lines, even though they all are growth-inhibited by TGF-beta. Thus, we show has likely reflects concurrent gene mutations activation state pathways controlled genes.
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