Organic bases of late-life depression: a critical update

摘要: Late-life depression (LLD) is frequently associated with cognitive impairment and increases the risk of subsequent dementia. Cerebrovascular disease, deep white matter lesions, Alzheimer disease (AD) dementia Lewy bodies (DLB) have all been hypothesized to contribute this increased risk, a host studies looked at interplay between cerebrovascular LLD. This has resulted in new concepts LLD, such as “vascular depression”, but despite multiple magnetic resonance imaging (MRI) field, relationship structural changes human brain LLD still controversial. While pathological findings suicide some elderly persons revealed lacunes, small vessel AD-related lesions or neurodegenerative pathologies, recent autopsy data challenged role subcortical lacunes major morphological substrates depressive symptoms well poorer executive function memory. Several neuropathological studies, including personal clinico-pathological study cohort age-matched controls confirmed that periventricular demyelination are usually unrelated occurrence In same line, show early-onset not an acceleration age-related changes. Very on critical glia-modulating neuronal dysfunction degeneration discussed.