Cooperation of Non-Effective Concentration of Glutamatergic System Modulators and Antioxidant Against Oxidative Stress Induced by Quinolinic Acid
作者： Fernando Dobrachinski , Luiza Lena Bastos , Jessika Cristina Bridi , Cristiane Lenz Dalla Corte , Daiana Silva de Ávila
DOI: 10.1007/S11064-012-0820-3
关键词:
摘要: Excessive formation of reactive oxygen species (ROS) and disruption glutamate uptake have been hypothesized as key mechanisms contributing to quinolinic acid (QA)-induced toxicity. Thus, here we investigate if the use diphenyl diselenide (PhSe)2, guanosine (GUO) MK-801, alone or in combination, could protect rat brain slices from QA-induced QA (1 mM) increased ROS formation, thiobarbituric substances (TBARS) decreased cell viability after 2 h exposure. (PhSe)2 μM) protected against this cortex striatum also prevented decreases induced by QA. (5 hippocampus. GUO (10 100 blocked increase caused MK-801 (20 abolished pro-oxidant effect When noneffective concentrations were used combination produced a decrease mainly + MK-801. These results demonstrate that be effective avoid toxic effects high Furthermore, data obtained cellular assays suggest different pathways amelioration toxicity present neurodegenerative process.
springer.com
sci-hub.se 参考文章(67)
Nady Braidy, Ross Grant, Seray Adams, Bruce J. Brew, Gilles J. Guillemin, Mechanism for Quinolinic Acid Cytotoxicity in Human Astrocytes and Neurons Neurotoxicity Research. ,vol. 16, pp. 77- 86 ,(2009) , 10.1007/S12640-009-9051-Z
Cristina W. Nogueira, Gilson Zeni, João B. T. Rocha, Organoselenium and Organotellurium Compounds: Toxicology and Pharmacology Chemical Reviews. ,vol. 104, pp. 6255- 6285 ,(2004) , 10.1021/CR0406559
Simone Molz, Dal-Cim Tharine, Helena Decker, Carla I. Tasca, GMP prevents excitotoxicity mediated by NMDA receptor activation but not by reversal activity of glutamate transporters in rat hippocampal slices Brain Research. ,vol. 1231, pp. 113- 120 ,(2008) , 10.1016/J.BRAINRES.2008.07.009
Cristina Wayne Nogueira, Liane Nanci Rotta, Marcos Luiz Perry, Diogo Onofre Souza, João Batista Teixeira da Rocha, Diphenyl diselenide and diphenyl ditelluride affect the rat glutamatergic system in vitro and in vivo. Brain Research. ,vol. 906, pp. 157- 163 ,(2001) , 10.1016/S0006-8993(01)02165-5
V. Pérez-De La Cruz, C. González-Cortés, S. Galván-Arzate, O.N. Medina-Campos, F. Pérez-Severiano, S.F. Ali, J. Pedraza-ChaverrÍ, A. Santamaría, Excitotoxic brain damage involves early peroxynitrite formation in a model of Huntington's disease in rats: protective role of iron porphyrinate 5,10,15,20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III). Neuroscience. ,vol. 135, pp. 463- 474 ,(2005) , 10.1016/J.NEUROSCIENCE.2005.06.027
Félix A Soares, André P Schmidt, Marcelo Farina, Marcos ES Frizzo, Rejane G Tavares, Luı́s VC Portela, Diogo R Lara, Diogo O Souza, None, Anticonvulsant effect of GMP depends on its conversion to guanosine Brain Research. ,vol. 1005, pp. 182- 186 ,(2004) , 10.1016/J.BRAINRES.2004.01.053
Roger F. Castilho, Alicia J. Kowaltowski, Anibal E. Vercesi, The irreversibility of inner mitochondrial membrane permeabilization by Ca2+ plus prooxidants is determined by the extent of membrane protein thiol cross-linking Journal of Bioenergetics and Biomembranes. ,vol. 28, pp. 523- 529 ,(1996) , 10.1007/BF02110442
W M H Behan, M McDonald, L G Darlington, T W Stone, Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: protection by melatonin and deprenyl. British Journal of Pharmacology. ,vol. 128, pp. 1754- 1760 ,(1999) , 10.1038/SJ.BJP.0702940
Elsa Regina Vinadé, André Prato Schmidt, Marcos Emı́lio Santos Frizzo, Ivan Izquierdo, Elaine Elisabetsky, Diogo Onofre Souza, None, Chronically administered guanosine is anticonvulsant, amnesic and anxiolytic in mice Brain Research. ,vol. 977, pp. 97- 102 ,(2003) , 10.1016/S0006-8993(03)02769-0
Renata Ciccarelli, Patrizia Di Iorio, Patricia Giuliani, Iolanda D'Alimonte, Patrizia Ballerini, Francesco Caciagli, Michel P. Rathbone, Rat cultured astrocytes release guanine-based purines in basal conditions and after hypoxia/hypoglycemia. Glia. ,vol. 25, pp. 93- 98 ,(1999) , 10.1002/(SICI)1098-1136(19990101)25:1<93::AID-GLIA9>3.0.CO;2-N