Facial phenotyping by quantitative photography reflects craniofacial morphology measured on magnetic resonance imaging in Icelandic sleep apnea patients.

摘要: STUDY OBJECTIVES (1) To determine whether facial phenotype, measured by quantitative photography, relates to underlying craniofacial obstructive sleep apnea (OSA) risk factors, with magnetic resonance imaging (MRI); (2) assess these associations are independent of body size and obesity. DESIGN Cross-sectional cohort. SETTING Landspitali, The National University Hospital, Iceland. PARTICIPANTS One hundred forty patients (87.1% male) from the Icelandic Sleep Apnea Cohort who had both calibrated frontal profile photographs upper airway MRI. Mean ± standard deviation age 56.1 10.4 y, mass index 33.5 5.05 kg/m(2), on-average severe OSA (apnea-hypopnea 45.4 19.7 h(-1)). INTERVENTIONS N/A. MEASUREMENTS AND RESULTS Relationships between surface dimensions (photos) bony soft-tissue volumes (MRI) was assessed using canonical correlation analysis. Photo MRI datasets related in four significant correlations, primarily driven measurements maxillary-mandibular relationship (r = 0.8, P < 0.0001), lower face height 0.76, (3) mandibular length 0.67, (4) tongue volume 0.52, 0.01). Correlations 1, 2, 3 were unchanged when controlled for weight neck waist circumference. However, no longer significant, suggesting relate as a result CONCLUSIONS Significant found variable sets photography This study confirms that photographic phenotype reflects aspects skeletal abnormalities associated OSA. Therefore, phenotyping may be useful tool intermediate phenotypes OSA, particularly large-scale studies.