Low-dose Intravenous Ketamine Potentiates Epidural Analgesia after Thoracotomy
作者： Manzo Suzuki , Syuji Haraguti , Kikuzo Sugimoto , Takehiko Kikutani , Yoichi Shimada
DOI: 10.1097/00000542-200607000-00020
关键词:
摘要: BACKGROUND: Ketamine potentiates intravenous or epidural morphine analgesia. The authors hypothesized that very-low-dose ketamine infusion reduces acute and long-term postthoracotomy pain. METHODS: Forty-nine patients scheduled to undergo open thoracotomy were randomly assigned receive one of two anesthesia regimens: continuous ropivacaine morphine, along with (0.05 mg . kg(-1) h(-1) [approximately 3 mg/h], group, n = 24) placebo (saline, control 25). Epidural analgesia was continued for 2 days after surgery, days. Pain assessed at 6, 12, 24, 48 h surgery. Patients asked about their pain, abnormal sensation on the wound, inconvenience in daily life 7 1, 3, 6 months RESULTS: visual analog scale scores pain rest coughing 24 lower group than (pain rest, 9 +/- 11 vs. 25 20 18 13; coughing, 26 16 50 17 30 43 18, mean SD; P 0.002 0.01, < 0.0001 0.02, respectively). numerical rating baseline 1 significantly (0.5 [0-4] [0-5] 0 1.5 [0-6], median [range], respectively; 0.02). Three a higher number taking medication (2 9; 0.03). CONCLUSIONS: Very-low-dose h(-1)) potentiated morphine-ropivacaine reduced
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