Effect of chemotherapy on primordial follicular reserve of rat: An animal model of premature ovarian failure and infertility
作者： Mehmet Sait Yucebilgin , Mustafa Cosan Terek , Aydin Ozsaran , Fuat Akercan , Osman Zekioglu
DOI: 10.1111/J.1479-828X.2004.00143.X
关键词:
摘要: Aim: To determine the effect of paclitaxel and cisplatin in reduction primordial follicular reserve rat. Material methods: Thirty young female rats were divided randomly into three groups 10 each. Paclitaxel 7.5 mg/kg 5 mg/kg administered intraperitoneally a single dose sterile technique to (n = 10), (n = 10) groups, saline solution was given control group (n = 10). assess effects chemotherapeutic agents on follicles, oophorectomised 7 days after administration agents. Haematoxylin eosin staining used number follicles. Primordial follicles identified by presence an oocyte encapsulated partially or completely layer flattened cells without theca at ovarian cortex. Results: The 23.1 ± 16.1 decreased significantly both compared (10.3 ± 13.0 13.9 ± 15.2 respectively) (P = 0.001 P = 0.01, respectively). difference between insignificant (P = 0.465). Conclusion: high causes depletion However, no significant observed two
sci-hub.se 参考文章(9)
Jacob Tangir, Daniel Zelterman, Wenging Ma, Peter E Schwartz, Reproductive function after conservative surgery and chemotherapy for malignant germ celltumors of the ovary Obstetrics & Gynecology. ,vol. 101, pp. 251- 257 ,(2003) , 10.1016/S0029-7844(02)02508-5
Fatih Gücer, Petek Balkanlı-Kaplan, Latife Doganay, M.Ali Yüce, Ebru Demiralay, N.Cenk Sayin, Turgut Yardım, Effect of paclitaxel on primordial follicular reserve in mice Fertility and Sterility. ,vol. 76, pp. 628- 629 ,(2001) , 10.1016/S0015-0282(01)01959-8
Tzu-Hao Wang, Hsin-Shih Wang, Yung-Kwei Soong, Paclitaxel-induced cell death: Where the cell cycle and apoptosis come together Cancer. ,vol. 88, pp. 2619- 2628 ,(2000) , 10.1002/1097-0142(20000601)88:11<2619::AID-CNCR26>3.0.CO;2-J
Mariana Gerschenson, Catherine Y Paik, Emily L Gaukler, Bhalchandra A Diwan, Miriam C Poirier, Cisplatin exposure induces mitochondrial toxicity in pregnant rats and their fetuses. Reproductive Toxicology. ,vol. 15, pp. 525- 531 ,(2001) , 10.1016/S0890-6238(01)00156-3
Bill J. Smith, David R. Plowchalk, I.Glenn Sipes, Donald R. Mattison, Comparison of random and serial sections in assessment of ovarian toxicity. Reproductive Toxicology. ,vol. 5, pp. 379- 383 ,(1991) , 10.1016/0890-6238(91)90097-Y
JE Sanders, J Hawley, W Levy, T Gooley, CD Buckner, HJ Deeg, K Doney, R Storb, K Sullivan, R Witherspoon, FR Appelbaum, Pregnancies following high-dose cyclophosphamide with or without high- dose busulfan or total-body irradiation and bone marrow transplantation Blood. ,vol. 87, pp. 3045- 3052 ,(1996) , 10.1182/BLOOD.V87.7.3045.BLOODJOURNAL8773045
John B Mailhes, Mary J Carabatsos, Daniel Young, Steve N London, Maria Bell, David F Albertini, Taxol-induced meiotic maturation delay, spindle defects, and aneuploidy in mouse oocytes and zygotes. Mutation Research. ,vol. 423, pp. 79- 90 ,(1999) , 10.1016/S0027-5107(98)00228-0
D. Meirow, H. Lewis, D. Nugent, M. Epstein, Subclinical depletion of primordial follicular reserve in mice treated with cyclophosphamide: clinical importance and proposed accurate investigative tool Human Reproduction. ,vol. 14, pp. 1903- 1907 ,(1999) , 10.1093/HUMREP/14.7.1903
Shuichi KAI, Hisashi KOHMURA, Eiko HIRAIWA, Shigeru KOIZUMI, Katsumi ISHIKAWA, Shigeo KAWANO, Kohji KUROYANAGI, Norimichi HATTORI, Hirotaka CHIKAZAWA, Hiroshi KONDOH, Kayo SAKAKURA, Toshihito KADOTA, Norimitsu TAKAHASHI, [Reproductive and developmental toxicity studies of paclitaxel. (I)--Intravenous administration to rats prior to and in the early stages of pregnancy]. Journal of Toxicological Sciences. ,vol. 19, pp. 57- 67 ,(1994) , 10.2131/JTS.19.SUPPLEMENTI_57