摘要: Nociceptin/orphanin FQ(1–13) amide is the smallest fragment of nociceptin/orphanin FQ (N/OFQ) that binds to and activates its cognate receptor, ORL1 ( Calo et al ., 1996 ; Dooley Houghten, ). agonists, such as this peptide, are active on cells in central nervous immune systems. Their actions include, but not limited to, modulation nociceptive sensitivity, anxiolytic actions, orexogenic bradycardia, diuresis al., 2000 Unlike other opioid N/OFQ-like agonists do appear have addictive potential Devine
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