Construction and immunogenic studies of a mFc fusion receptor binding domain (RBD) of spike protein as a subunit vaccine against SARS-CoV-2 infection.

作者: Xiaoxiao Qi , Bixia Ke , Qian Feng , Deying Yang , Qinghai Lian

DOI: 10.1039/D0CC03263H

关键词:

摘要: … , which significantly contributes to the uptake and … to the SARS-CoV-2 S protein hectodomain with about 15 nM … -CoV-2 RBD binding to the host cell receptor ACE2. Most importantly, the …

参考文章(27)
Saman Soleimanpour, Hadi Farsiani, Arman Mosavat, Kiarash Ghazvini, Mohammad Reza Akbari Eydgahi, Mojtaba Sankian, Hamid Sadeghian, Zahra Meshkat, Seyed Abdolrahim Rezaee, APC targeting enhances immunogenicity of a novel multistage Fc-fusion tuberculosis vaccine in mice Applied Microbiology and Biotechnology. ,vol. 99, pp. 10467- 10480 ,(2015) , 10.1007/S00253-015-6952-Z
Lanying Du, Yuxian He, Yusen Zhou, Shuwen Liu, Bo-Jian Zheng, Shibo Jiang, The spike protein of SARS-CoV — a target for vaccine and therapeutic development Nature Reviews Microbiology. ,vol. 7, pp. 226- 236 ,(2009) , 10.1038/NRMICRO2090
Guochao Liao, Zhifang Zhou, Zhongwu Guo, Synthesis and immunological study of α-2,9-oligosialic acid conjugates as anti-group C meningitis vaccines. Chemical Communications. ,vol. 51, pp. 9647- 9650 ,(2015) , 10.1039/C5CC01794G
Jiaming Lan, Yao Deng, Hong Chen, Guangwen Lu, Wen Wang, Xiaojuan Guo, Zhuozhuang Lu, George F. Gao, Wenjie Tan, Tailoring Subunit Vaccine Immunity with Adjuvant Combinations and Delivery Routes Using the Middle East Respiratory Coronavirus (MERS-CoV) Receptor-Binding Domain as an Antigen PLoS ONE. ,vol. 9, pp. e112602- ,(2014) , 10.1371/JOURNAL.PONE.0112602
Lanying Du, Guangyu Zhao, Yuxian He, Yan Guo, Bo-Jian Zheng, Shibo Jiang, Yusen Zhou, Receptor-binding domain of SARS-CoV spike protein induces long-term protective immunity in an animal model. Vaccine. ,vol. 25, pp. 2832- 2838 ,(2007) , 10.1016/J.VACCINE.2006.10.031
Alexander N. Zakhartchouk, Chetna Sharon, Malathy Satkunarajah, Thierry Auperin, Sathiyanarayanan Viswanathan, George Mutwiri, Martin Petric, Raymond H. See, Robert C. Brunham, B. Brett Finlay, Cheryl Cameron, David J. Kelvin, Alan Cochrane, James M. Rini, Lorne A. Babiuk, Immunogenicity of a receptor-binding domain of SARS coronavirus spike protein in mice: Implications for a subunit vaccine Vaccine. ,vol. 25, pp. 136- 143 ,(2007) , 10.1016/J.VACCINE.2006.06.084
Yuxian He, Jingjing Li, Wenhui Li, Sara Lustigman, Michael Farzan, Shibo Jiang, Cross-neutralization of human and palm civet severe acute respiratory syndrome coronaviruses by antibodies targeting the receptor-binding domain of spike protein. Journal of Immunology. ,vol. 176, pp. 6085- 6092 ,(2006) , 10.4049/JIMMUNOL.176.10.6085
Daniel M. Czajkowsky, Jun Hu, Zhifeng Shao, Richard J. Pleass, Fc‐fusion proteins: new developments and future perspectives Embo Molecular Medicine. ,vol. 4, pp. 1015- 1028 ,(2012) , 10.1002/EMMM.201201379
Takehiro Ura, Kenji Okuda, Masaru Shimada, None, Developments in Viral Vector-Based Vaccines. Vaccine. ,vol. 2, pp. 624- 641 ,(2014) , 10.3390/VACCINES2030624
Kiarash Ghazvini, Arman Mosavat, Saman Soleimanpour, Seyed Abdolrahim Rezaee, Hamid Sadeghian, Saeid Amel Jamehdar, Hadi Farsiani, Mohammad Reza Akbari Eydgahi, Zahra Meshkat, Ali Asghar Baghani, Masoud Yousefi, CFP10: mFcγ2 as a novel tuberculosis vaccine candidate increases immune response in mouse. Iranian Journal of Basic Medical Sciences. ,vol. 20, pp. 122- 130 ,(2017) , 10.22038/IJBMS.2017.8231