The Emerging Roles of Early Protein Folding Events in the Secretory Pathway in the Development of Neurodegenerative Maladies.

摘要: Although protein aggregation and deposition are unifying features of various neurodegenerative disorders, recent studies indicate that different mechanisms can lead to the development same malady. Among these, failure in early folding maturation emerge as key mechanistic events manifestation a myriad illnesses including Alzheimer’s disease prion disorders. Here we delineate cascade steps nascent polypeptides undergo secretory pathway become functional proteins, chaperones supervise assist this process, focusing on subgroup proline cis/trans isomerases. We also describe whose was found be an underlying event initiates run-up towards neurodegeneration well activity impairs homeostasis (proteostasis) thus, promotes these maladies. Finally, discuss roles aggregate sites cellular attempt maintain proteostasis point at potential targets for therapeutic interventions.