Hepatocellular Carcinoma in Cirrhotic and Noncirrhotic Livers: A Clinico-Histopathologic Study of 804 North American Patients

摘要: This study examined clinico-histopathologic differences between North American patients who developed hepatocellular carcinoma with and without cirrhosis. Histologic slides clinical records of cases were reviewed. Cases classified according to defined histopathologic criteria. Analyses performed using appropriate tests. A total 42.6% noncirrhotic. The trabecular type was the most common growth pattern in both groups. Patients cirrhosis significantly older, had high grade tumors, local portal venous invasion more often than Encapsulated tumors occurred survived longer (P < .0001) a better 5-year survival experience. On average, cirrhosis, serum aspartate transaminase bilirubin greater, albumin lower. In general, tended be less well differentiated those found among pathology, natural history, prognosis this tumor is influenced by presence or absence nonneoplastic liver, portends poorer prognosis.