The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y.

摘要: Abstract This review aims to give a brief overview of NPY receptor distribution and physiology in the brain summarizes series studies, test by region region, aimed at identification subtypes neuronal circuitry mediating anxiolytic-like effects NPY. We conclude that from four known rat (Y1, Y2, Y4, Y5), only Y1 can be linked anxiety-regulation with certainty forebrain, Y2 may have role pons. Microinjection studies antagonists support hypothesis amygdala, dorsal periaqueductal gray matter, dorsocaudal lateral septum locus coeruleus form neuroanatomical substrate mediates The release these areas is likely phasic, as are silent on their own. However, constant NPY-ergic tone seems exist gray, where had anxiogenic-like effects. endogenous has an important reducing anxiety serves physiological stabilizer neural activity circuits involved regulation arousal anxiety.