Altered Excitation-Contraction Coupling in Human Chronic Atrial Fibrillation.
作者： Sandeep V. Pandit , Antony J. Workman , Eleonora Grandi
DOI: 10.4022/JAFIB.495
关键词:
摘要: This review focuses on the (mal)adaptive processes in atrial excitation-contraction coupling occurring patients with chronic fibrillation. Cellular remodeling includes shortening of action potential duration and effective refractory period, depressed intracellular Ca2+ transient, reduced myocyte contractility. Here we summarize current knowledge ionic bases underlying these changes. Understanding molecular mechanisms excitation-contraction-coupling fibrillating human atria is important to identify new targets for AF therapy.
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