The inflammatory effect of nucleus pulposus. A possible element in the pathogenesis of low-back pain.

摘要: Homogenized autogenous nucleus pulposus was injected into the lumbar epidural space of four dogs through an indwelling catheter. After daily injections material over 5 to 7 days, were killed at 5, 7, 14, or 21 days after first injection. In that served as controls, normal saline on identical schedule and times experimental group. Evaluation dural sac, spinal cord its roots performed by gross inspection microscopic analysis. There evidence inflammatory response nuclear injected, but no occurred in control