Vitamin D cell signalling in health and disease.

摘要: Vitamin D deficiency has been linked to many human diseases such as Alzheimer's disease (AD), Parkinson's (PD), multiple sclerosis (MS), hypertension and cardiovascular disease. A phenotypic stability hypothesis, which is developed in this review, attempts describe how vital hormone acts maintain healthy cellular functions. This role of a guardian seems depend on its ability the redox Ca(2+) signalling systems. It argued that primary action expression those components responsible for stabilizing low resting state these two pathways. facilitated through vitamin increase both Nrf2 anti-ageing protein Klotho, are also major regulators signalling. decline levels will lead regulatory network may account why so man, have deficiency, associated with dysregulation ROS