A case report of adult T-cell leukaemia/lymphoma.

摘要: Adult T-cell leukaemia/lymphoma (ATLL) is a rare T lymphoproliferative disorder which aetiologically linked with human lymphotropic virus type-1 (HTLV-1). HTLV-1 endemic in Japan, Caribbean and Africa. The highest incidence of ATLL Japan although sporadic cases have been reported elsewhere the world. We describe case an unusual presentation we believe first Malaysia based on our literature search. A 51-year-old Indian lady was referred to University Malaya Medical Centre for incidental finding lymphocytosis while being investigated pallor giddiness. Clinical examination revealed bilateral shotty cervical lymph nodes no hepato-splenomegaly or skin lesions. Laboratory investigations showed absolute (38 x 10(9)/L) mildly increased serum lactate dehydrogenase. peripheral blood smear presence predominantly small medium sized, non-flower lymphocytes. bone marrow similar findings prominent lymphocytosis. Immunophenotyping mononuclear cells CD3+, CD4+, CD5+, CD7- CD25+ characteristic phenotype. infection confirmed by proviral DNA tumor using conventional Polymerase Chain Reaction (PCR) real-time PCR. Here, discuss pathogenesis characteristics as well detection real time