WNT pathway deregulation in adrenal cortex tumorigenesis
作者： James Wilmouth , Julie Olabe , Florence Roucher-Boulez , Pierre Val
DOI: 10.1016/J.COEMR.2019.08.016
关键词:
摘要: Abstract Since 2005 and the discovery of canonical Wingless iNTegration 1 (WNT) pathway activation in adrenocortical tumors, a large body work has identified diverse roles this signaling adrenal homeostasis disease. This review focuses on WNT deregulation benign malignant cortex tumors. It covers role CTNNB1 APC alterations provides data newly regulator ZNRF3. raises questions mechanisms that may underlie broad effects tumorigenesis, which range from development nonsecreting tumors to aggressive cortisol-producing carcinomas. Altogether it highlights central adrenal, emphasizing need for therapeutic targeting diseases.
sci-hub.se 参考文章(68)
Rebecca Yates, Harshini Katugampola, Dominic Cavlan, Katy Cogger, Eirini Meimaridou, Claire Hughes, Louise Metherell, Leonardo Guasti, Peter King, Adrenocortical Development, Maintenance, and Disease Current Topics in Developmental Biology. ,vol. 106, pp. 239- 312 ,(2013) , 10.1016/B978-0-12-416021-7.00007-9
Tobias Åkerström, Rajani Maharjan, Holger Sven Willenberg, Kenko Cupisti, Julian Ip, Ana Moser, Peter Stålberg, Bruce Robinson, K. Alexander Iwen, Henning Dralle, Martin K. Walz, Hendrik Lehnert, Stan Sidhu, Celso Gomez-Sanchez, Per Hellman, Peyman Björklund, Activating mutations in CTNNB1 in aldosterone producing adenomas Scientific Reports. ,vol. 6, pp. 19546- 19546 ,(2016) , 10.1038/SREP19546
Rossella Libé, Adrenocortical carcinoma (ACC): diagnosis, prognosis, and treatment. Frontiers in Cell and Developmental Biology. ,vol. 3, pp. 45- 45 ,(2015) , 10.3389/FCELL.2015.00045
J Papkoff, A M Brown, H E Varmus, The int-1 proto-oncogene products are glycoproteins that appear to enter the secretory pathway. Molecular and Cellular Biology. ,vol. 7, pp. 3978- 3984 ,(1987) , 10.1128/MCB.7.11.3978
Jamie N. Anastas, Randall T. Moon, WNT signalling pathways as therapeutic targets in cancer Nature Reviews Cancer. ,vol. 13, pp. 11- 26 ,(2013) , 10.1038/NRC3419
Madson Q. Almeida, Monalisa F. Azevedo, Paraskevi Xekouki, Eirini I. Bimpaki, Anelia Horvath, Michael T. Collins, Lefkothea P. Karaviti, George S. Jeha, Nisan Bhattacharyya, Chris Cheadle, Tonya Watkins, Isabelle Bourdeau, Maria Nesterova, Constantine A. Stratakis, Activation of cyclic AMP signaling leads to different pathway alterations in lesions of the adrenal cortex caused by germline PRKAR1A defects versus those due to somatic GNAS mutations. The Journal of Clinical Endocrinology and Metabolism. ,vol. 97, ,(2012) , 10.1210/JC.2011-3000
Michael D. Gordon, Roel Nusse, Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors Journal of Biological Chemistry. ,vol. 281, pp. 22429- 22433 ,(2006) , 10.1074/JBC.R600015200
Mimi Tadjine, Antoine Lampron, Lydia Ouadi, Isabelle Bourdeau, Frequent mutations of β‐catenin gene in sporadic secreting adrenocortical adenomas* Clinical Endocrinology. ,vol. 68, pp. 264- 270 ,(2007) , 10.1111/J.1365-2265.2007.03033.X
Coralie Drelon, Annabel Berthon, Mickael Mathieu, Antoine Martinez, Pierre Val, Adrenal cortex tissue homeostasis and zonation: A WNT perspective Molecular and Cellular Endocrinology. ,vol. 408, pp. 156- 164 ,(2015) , 10.1016/J.MCE.2014.12.014
L. Groussin, J. Bertherat, C. Gicquel, Y. le Bouc, X. Bertagna, Insights into the molecular biology of adrenocortical tumors. Experimental and Clinical Endocrinology & Diabetes. ,vol. 115, pp. 175- 178 ,(2007) , 10.1055/S-2007-970411