Regulation of Keap1-Nrf2 signaling: The role of epigenetics.
作者： David Cheng , Renyi Wu , Yue Guo , Ah-Ng Tony Kong
DOI: 10.1016/J.COTOX.2016.10.008
关键词:
摘要: Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related 2 (NFE2L2/Nrf2) signaling pathway is a pivotal player in the antioxidant response to oxidative and electrophilic stress can play role many human diseases. Activation or inhibition of Nrf2 has been an approach treating diseases such as cancer regulation this thoroughly studied. Recently, epigenetics emerged another layer for regulating Keap1-Nrf2. Epigenetics modification defined heritable changes gene expression without changing DNA sequence various modifications have found be involved Therefore, targeting these epigenetic on Keap1-Nrf2 provides potential modulating treat disease. In review, several important recent findings perspectives are discussed shared.
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