Voltage-sensitive Na+ channels increase in number in newborn rat brain after in utero hypoxia.
作者： Ying Xia , Gabriel G. Haddad
DOI: 10.1016/0006-8993(94)91459-1
关键词:
摘要: The effect of chronic in utero hypoxia on voltage-sensitive Na+ channels newborn rat brain was investigated by means ligand binding and autoradiography with [3H]saxitoxin (STX, channel ligand). We found that: (a) properties were different between hypoxic control brains alinear Scatchard plots versus linear ones the control; (b) STX density increased greatly response to stimulation; (c) hypoxia-induced increase heterogeneous various areas. conclude that alters expression induces an up-regulation as a function area. This is first report this phenomenon we believe may play important role etiology neurological disorders such epilepsy.
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