In vitro ovicidal and larvicidal activities of some saponins and flavonoids against parasitic nematodes of goats.
作者： Acidália Carine Vieira Santos , Francianne Oliveira Santos , Hélimar Gonçalves Lima , Gisele Dias Da Silva , Rosangela Soares Uzêda
DOI: 10.1017/S0031182018000689
关键词:
摘要: This study assessed the anthelmintic activity of plant-derived compounds against gastrointestinal nematodes goats using egg hatch and larval motility assays. The tested were saponins (digitonin aescin) their respective sapogenins (aglycones), hecogenin acetate flavonoids (catechin, hesperidin, isocordoin a mixture cordoin). Additionally, cytotoxicity active substances was analysed on Vero cell through 3-4,5-dimethylthiazol-2-yl,2,5diphenyltetrazolium bromide (MTT) propidium iodide (PI) tests. Significant reduction hatching (P 90%). Nevertheless, higher observed in MTT assay, with IC50 0.20 mg mL-1 (aescin) 0.0074 (digitonin). Aescin digitonin have pronounced vitro effect glycone portion these plays an important role this activity.
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