Serum CCN3 levels are increased in type 2 diabetes mellitus and associated with obesity, insulin resistance and inflammation
作者： Jiao-Yang Li , Ya-Di Wang , Xiao-Yan Qi , Li Ran , Tao Hong
DOI: 10.1016/J.CCA.2019.03.006
关键词:
摘要: Abstract Backgroud CCN3 is a novel adipokine and has emerged as potential metabolic regulator. However, information regarding the role of in type 2 diabetes mellitus (T2DM) remains unclear. This study measured for first time serum levels T2DM explored correlations between its various parameters humans. Methods A total 219 newly diagnosed (nT2DM) patients 205 healthy control subjects, matched age sex ratio, were enrolled. Circulating TNF-α, IL-6 MCP-1 by ELISA. The anthropometric assessment biochemical evaluation done all subjects. OGTT performed 34 individuals to investigate association with glucose. Results Serum significantly higher nT2DM compared those controls (6.71[4.88, 8.56] vs. 4.51[3.55, 5.99] ng/ml, P 0.05). Conclusions Elevation supports hypothesis that may serve risk factor associated pathogenesis T2DM.
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