Activation and regulation of Toll-like receptors 2 and 1 in human leprosy.
作者： Stephan R Krutzik , Maria Teresa Ochoa , Peter A Sieling , Satoshi Uematsu , Yolanda W Ng
DOI: 10.1038/NM864
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摘要: The expression and activation of Toll-like receptors (TLRs) was investigated in leprosy, a spectral disease which clinical manifestations correlate with the type immune response mounted toward Mycobacterium leprae. TLR2-TLR1 heterodimers mediated cell by killed M. leprae, indicating presence triacylated lipoproteins. A genome-wide scan leprae detected 31 putative Synthetic lipopeptides representing 19-kD 33-kD lipoproteins activated both monocytes dendritic cells. Activation enhanced type-1 cytokines inhibited type-2 cytokines. In addition, interferon (IFN)-gamma granulocyte-macrophage colony-stimulating factor (GM-CSF) TLR1 cells, respectively, whereas IL-4 downregulated TLR2 expression. were more strongly expressed lesions from localized tuberculoid form (T-lep) as compared disseminated lepromatous (L-lep) disease. These data provide evidence that regulated TLRs at site contribute to host defense against microbial pathogens.
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