Glucocorticoid Receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor
作者： Ioanna Petta , Nadia Bougarne , Jolien Vandewalle , Lien Dejager , Sofie Vandevyver
DOI: 10.1038/S41598-017-09246-6
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摘要: The transcriptional activity of the glucocorticoid receptor (GR) is co-determined by its ability to recruit a vast and varying number cofactors. We here identify Striatin-3 (STRN3) as novel interaction partner GR that interferes with GR’s ligand-dependent transactivation capacity. Remarkably, STRN3 selectively affects only GR-dependent leaves transrepression mechanisms unhampered. found down-regulates an additional recruitment catalytic subunit protein phosphatase 2A (PPP2CA) GR. hypothesize existence functional trimeric complex in nucleus, able dephosphorylate at serine 211, known marker for target gene-dependent manner. presence appears absolute prerequisite PPP2CA engage Herein, C-terminal domain essential, reflecting ligand-dependency, yet other parts are also needed create contacts STRN3.
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