Evaluation on subcellular partitioning and biodynamics of pulse copper toxicity in tilapia reveals impacts of a major environmental disturbance.

摘要: Fluctuation exposure of trace metal copper (Cu) is ubiquitous in aquatic environments. The purpose this study was to investigate the impacts chronically pulsed on biodynamics and subcellular partitioning Cu freshwater tilapia (Oreochromis mossambicus). Long-term 28-day experiments were performed explore toxicokinetics/toxicodynamics tilapia. Subcellular linking with a influx scheme used estimate detoxification elimination rates. A biotic ligand model-based damage assessment model take into account environmental effects biological mechanisms toxicity. We demonstrated that probability causing 50% susceptibility risk response pulse generic Taiwan aquaculture ponds ~33% adverse physiologically associated, metabolically active pool, implicating no significant for suggest our integrated ecotoxicological models chronic measurements can facilitate framework provides predictive tool preventive reduction strategies fish exposed stressors.