Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivity.
作者： P M Fisher , C C Meltzer , S K Ziolko , J C Price , E L Moses-Kolko
DOI: 10.1038/NN1780
关键词:
摘要: We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity blood oxygenation level–dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. found a significant inverse relationship wherein autoreceptor density predicted notable 30–44% variability reactivity. Our data suggest potential molecular mechanism by which reduced capacity for negative feedback regulation 5-HT release is associated with increased
nature.com
sci-hub.se 参考文章(11)
Pierre Blier, Claude de Montigny, Serotonin and Drug-Induced Therapeutic Responses in Major Depression, Obsessive–Compulsive and Panic Disorders Neuropsychopharmacology. ,vol. 21, pp. 91- 98 ,(1999) , 10.1016/S0893-133X(99)00036-6
Gregor Hasler, Wayne C Drevets, Husseini K Manji, Dennis S Charney, Discovering endophenotypes for major depression. Neuropsychopharmacology. ,vol. 29, pp. 1765- 1781 ,(2004) , 10.1038/SJ.NPP.1300506
Sylvie Lemonde, Lisheng Du, David Bakish, Pavel Hrdina, Paul R. Albert, Association of the C(-1019)G 5-HT1A functional promoter polymorphism with antidepressant response. The International Journal of Neuropsychopharmacology. ,vol. 7, pp. 501- 506 ,(2004) , 10.1017/S1461145704004699
Kristen C Klemenhagen, Joshua A Gordon, Denis J David, René Hen, Cornelius T Gross, Increased fear response to contextual cues in mice lacking the 5-HT1A receptor. Neuropsychopharmacology. ,vol. 31, pp. 101- 111 ,(2006) , 10.1038/SJ.NPP.1300774
S. P. David, A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans. The Journal of Neuroscience. ,vol. 25, pp. 2586- 2590 ,(2005) , 10.1523/JNEUROSCI.3769-04.2005
Ramin V. Parsey, Maria A. Oquendo, R. Todd Ogden, Doreen M. Olvet, Norman Simpson, Yung-yu Huang, Ronald L. Van Heertum, Victoria Arango, J. John Mann, Altered Serotonin 1A Binding in Major Depression: A [carbonyl-C-11]WAY100635 Positron Emission Tomography Study Biological Psychiatry. ,vol. 59, pp. 106- 113 ,(2006) , 10.1016/J.BIOPSYCH.2005.06.016
Sylvie Lemonde, Gustavo Turecki, David Bakish, Lisheng Du, Pavel D. Hrdina, Christopher D. Bown, Adolfo Sequeira, Neena Kushwaha, Stephen J. Morris, Ajoy Basak, Xiao-Ming Ou, Paul R. Albert, Impaired Repression at a 5-Hydroxytryptamine 1A Receptor Gene Polymorphism Associated with Major Depression and Suicide The Journal of Neuroscience. ,vol. 23, pp. 8788- 8799 ,(2003) , 10.1523/JNEUROSCI.23-25-08788.2003
C. L. Parks, P. S. Robinson, E. Sibille, T. Shenk, M. Toth, Increased anxiety of mice lacking the serotonin1A receptor. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 10734- 10739 ,(1998) , 10.1073/PNAS.95.18.10734
Ahmad R Hariri, Venkata S Mattay, Alessandro Tessitore, Bhaskar Kolachana, Francesco Fera, David Goldman, Michael F Egan, Daniel R Weinberger, Serotonin Transporter Genetic Variation and the Response of the Human Amygdala Science. ,vol. 297, pp. 400- 403 ,(2002) , 10.1126/SCIENCE.1071829
Joseph E. LeDoux, Emotion Circuits in the Brain Annual Review of Neuroscience. ,vol. 23, pp. 155- 184 ,(2000) , 10.1146/ANNUREV.NEURO.23.1.155