Variation at the apolipoprotein (apo) AI-CIII-AIV gene cluster and apo B gene loci is associated with lipoprotein and apolipoprotein levels in Italian children.

摘要: We have used RFLPs of the apolipoprotein (apo) B gene and apo AI-CIII-AIV cluster to estimate genetic contribution variation at these loci variability plasmid lipid, lipoprotein, levels in 209 children from Sezze central Italy. The sample was randomly divided into group I (107 children) II (102 children). Four site polymorphisms (PvuII, XbaI, MspI, EcoRI) five (XmnI, PstI, SstI, PvuII-CIII, PvuII-AIV) were examined children. After adjustment for gender, age, body-mass index, both (PvuII-B, associated with significant effects on plasma AI, B, or high-density lipoprotein-cholesterol. that showed genotyped II. All three similar levels, though all magnitude smaller only statistically effect PvuII-B genotype AI levels. In total 7.4% variance explained by RFLP. addition, RFLP 5.7% variance. PvuII-CIII PvuII-AIV differences explaining 3.7%-5.7% Taken together, PvuII 17.7% phenotypic There evidence an nonlinearity genotypes individuals heterozygous polymorphism having highest No interaction between index shown covariance analysis. molecular explanation this is unclear. Our data show are lipoprotein Italian