Alterations of Subcortical Brain Structures in Paradoxical and Psychophysiological Insomnia Disorder.

摘要: Insomnia disorder (ID) is a common illness associated with mood and cognitive impairments. Subtyping ID an ongoing debate in sleep medicine, but the underlying mechanisms of each subtype poorly understood. Growing evidence suggests that subcortical brain structures play key roles pathophysiology its subtypes. Here, we aimed to investigate structural alteration regions patients two subtypes i.e., paradoxical psychophysiological insomnia. Fifty-five 49 healthy controls were recruited for this study T1-weighted images subjective objective parameters (i.e., Pittsburgh Sleep Quality Index polysomnography) collected from participants. Subcortical including hippocampus, amygdala, caudate, putamen, globus pallidus, nucleus accumbens, thalamus automatically segmented FSL. Volume shape (using surface vertices) structure compared between groups, controlled covariates, corrected multiple comparisons. In addition, correlations vertices or volumes calculated. The caudate's volume was smaller than controls. Compared controls, found regional shrinkage posterior thalamus, amygdala insomnia putamen Interestingly, comparing accumbens hippocampus observed. Both these alterations patients. Our results support differential role