Abstract P5-08-08: Risk reducing mastectomy in average and high risk patients with locally advanced triple negative breast cancer

摘要: Background: Women with locally advanced triple negative breast cancer (LA-TNBC) have a high risk of disease recurrence and are monitored clinically annual mammograms. High women, such as BRCA1/2 carriers, additionally for second primary cancers (BC) MRIs may opt reducing mastectomy (RRM) prophylactic measure. Our aim was to explore the clinical outcomes patients (pts) average BC (known carriers) who undergo RRM at time LA-TNBC diagnosis. Methods: We included 78 consecutive pts, stages IIB III, resectable unilateral disease, treated Sunnybrook Health Sciences Centre from 2009 2018. Pts did not systemic chemotherapy surgical treatment were excluded, well pts history prior BC. Medical records reviewed outcomes, pathology germline testing results. Log rank test used determine (TTR) overall survival (OS) differences among women underwent those not. Results: Median age diagnosis 49 years (range 27-82) 14 (18%) carriers. All neoadjuvant 27 (35%) presenting complete pathological response. Fifteen RRM, out which seven Mean follow up 34 (2-86) months, during 25 (32%) diagnosed distant none TTR 10 months 1-48) median OS 18 2-86). associated (p=0.45) (p=0.98). Presence also correlate (p=0.16) (p=0.21). Conclusions: In our cohort LA-TNBC, prognosis driven by rather than BCs. improved regardless status larger studies required support this procedure LA-TNBC. Citation Format: Neda Stjepanovic, Danilo Giffoni, Sonal Gandhi, Katarzyna Jerzak, Sharon Lemon, Karen Ott, Rossanna Pezo, Kathleen Pritchard, Samuel Tabbarah, Maureen Trudeau, Ellen Warner, William Tran, Andrea Eisen. Risk in [abstract]. In: Proceedings 2019 San Antonio Breast Cancer Symposium; Dec 10-14; Antonio, TX. Philadelphia (PA): AACR; Res 2020;80(4 Suppl):Abstract nr P5-08-08.