Pharmacokinetic and Pharmacodynamic Aspects of Focal and Targeted Delivery of Drugs
作者： David Stepensky
DOI: 10.1007/978-1-4614-9434-8_6
关键词:
摘要: In the past few decades significant progress has been made in development of drug delivery systems (DDSs) intended for targeted to its site action. Several dozens systemically or focally administered DDSs have approved clinical use. However, biofate drug/DDS following their administration is complex and controllable only a low extent. As result, amounts drugs reach target tissue, currently available are characterized by effectiveness and/or high magnitude adverse effects. this chapter, major pharmacokinetic pharmacodynamic parameters that govern presented, ways control drug/DDSs disposition enhance efficiency pharmacological responses discussed. This chapter’s focus on anticancer treatment solid tumors quantitative assessment analyzed factors/parameters.
springer.com
sci-hub.st 参考文章(41)
K. Dane Wittrup, Greg M. Thurber, Michael M. Schmidt, John J. Rhoden, Practical theoretic guidance for the design of tumor-targeting agents. Methods in Enzymology. ,vol. 503, pp. 255- 268 ,(2012) , 10.1016/B978-0-12-396962-0.00010-0
Lawrence K. Fung, Marian Shin, Betty Tyler, Henry Brem, W. Mark Saltzman, Chemotherapeutic drugs released from polymers : Distribution of 1,3-bis(2-chloroethyl)-1-nitrosourea in the rat brain Pharmaceutical Research. ,vol. 13, pp. 671- 682 ,(1996) , 10.1023/A:1016083113123
Hiroshi Maeda, Macromolecular therapeutics in cancer treatment: The EPR effect and beyond Journal of Controlled Release. ,vol. 164, pp. 138- 144 ,(2012) , 10.1016/J.JCONREL.2012.04.038
Davis Yohanes Arifin, Kam Yiu Timothy Lee, Chi-Hwa Wang, Chemotherapeutic drug transport to brain tumor. Journal of Controlled Release. ,vol. 137, pp. 203- 210 ,(2009) , 10.1016/J.JCONREL.2009.04.013
Johannes H. Proost, Pharmacokinetic/pharmacodynamic modeling in drug targeting Methods and Principles in Medicinal Chemistry. pp. 333- 370 ,(2001) , 10.1002/352760006XCH13
Nancy L. Elstad, Kirk D. Fowers, OncoGel (ReGel/paclitaxel) — Clinical applications for a novel paclitaxel delivery system Advanced Drug Delivery Reviews. ,vol. 61, pp. 785- 794 ,(2009) , 10.1016/J.ADDR.2009.04.010
Ameena Wadee, Viness Pillay, Yahya E Choonara, Lisa C du Toit, Clement Penny, Valence MK Ndesendo, Pradeep Kumar, Caragh S Murphy, None, Recent advances in the design of drug-loaded polymeric implants for the treatment of solid tumors Expert Opinion on Drug Delivery. ,vol. 8, pp. 1323- 1340 ,(2011) , 10.1517/17425247.2011.602671
Yechezkel (Chezy) Barenholz, Doxil®--the first FDA-approved nano-drug: lessons learned. Journal of Controlled Release. ,vol. 160, pp. 117- 134 ,(2012) , 10.1016/J.JCONREL.2012.03.020
Pakatip Ruenraroengsak, Janice M. Cook, Alexander T. Florence, Nanosystem drug targeting: Facing up to complex realities Journal of Controlled Release. ,vol. 141, pp. 265- 276 ,(2010) , 10.1016/J.JCONREL.2009.10.032
Jesse B. Wolinsky, Yolonda L. Colson, Mark W. Grinstaff, Local Drug Delivery Strategies for Cancer Treatment: Gels, Nanoparticles, Polymeric Films, Rods, and Wafers Journal of Controlled Release. ,vol. 159, pp. 14- 26 ,(2012) , 10.1016/J.JCONREL.2011.11.031