Lactoferrin Coating Improves the Antibacterial and Osteogenic Properties of Alkali-Treated Titanium with Nanonetwork Structures

摘要: Titanium and its alloys are the main dental implant materials used at present. The biological properties of pure titanium can be further improved by surface treatment methods. Alkali room temperature form nanonetwork structures (TNS) on surface, which has better osteoinductive ability than titanium. However, TNS does not possess antimicrobial properties, bacterial infection is one reasons for failure therapy. Therefore, it was focus our research to endow with certain premise maintaining ability. Because excellent broad-spectrum because promotes osteoblast-like cell growth, lactoferrin (LF) considered a promising prospect as material. In this study, bovine LF physiological concentration successfully coated TNS-LF composite Results from in vitro vivo experiments showed that had TNS. Bacterial attachment biofilm formation were also significantly decreased TNS-LF. study provided an experimental basis development osteoinduction-antimicrobial applications.