No association between genetic or epigenetic variation in insulin growth factors and antipsychotic-induced metabolic disturbances in a cross-sectional sample
作者： Tim Moons , Marc De Hert , Gunther Kenis , Wolfgang Viechtbauer , Jim van Os
DOI: 10.2217/PGS.14.46
关键词:
摘要: Aim: Second-generation antipsychotics (SGA) are known to induce metabolic disturbances. Genetic pathways, such as the IGF pathway could be associated with increased syndrome (MetS). Additionally, IGF2 methylation varies a function of environmental influences and is schizophrenia MetS. The current study aims evaluate whether genetic epigenetic variation in genes disturbances patients under treatment SGAs. Methods: Cross-sectional data from 438 spectrum disorder was analyzed. Using Sequenom MassARRAY iPLEXTM platform, 27 SNPs IGF1 receptors IGF1R IGF2R were genotyped. Methylation status seven CpG dinucleotides evaluated using MALDI-TOF spectrometer. Results & conclusion: There significant association between genotype, but no or variab...
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