Abnormal T-cell subset proportions in vitamin-A-deficient children

摘要: Although vitamin A deficiency in children seems to increase susceptibility infection and community trials have shown that supplementation can reduce childhood mortality from infectious diseases, the underlying biological mechanisms are largely unknown. We conducted a randomised, double-masked, placebo-controlled clinical trial among West Java, Indonesia, determine whether is associated with abnormalities T-cell subsets affects subsets. studied 55 aged 3-6 years--30 xerophthalmia 25 without. Acutely malnourished (< 80% of reference weight-for-height) were excluded. CD4/CD8 ratios proportions circulating CD4 naive, memory, CD8, CD45RA, CD45RO measured. Children had lower (p < 0.08), naive T cells 0.03), higher 0.04) than those without xerophthalmia. 26 given (60 mg retinol equivalent) 29 received placebo. 5 weeks later group 0.001), 0.01), 0.05) placebo group. Vitamin-A-deficient immune these reversible supplementation.