Long-term dietary restriction differentially affects the expression of BDNF and its receptors in the cortex and hippocampus of middle-aged and aged male rats.

摘要: Dietary restriction (DR) exerts significant beneficial effects in terms of aging and age-related diseases many organisms including humans. The present study aimed to examine the influence long-term DR on BDNF system at transcriptional translational levels cortex hippocampus middle-aged (12-month-old) aged (24-month-old) male Wistar rats. obtained results revealed that upregulated expression exon-specific transcripts both regions, followed by elevated mBDNF only animals. In animals, modulated protein increasing proBDNF declining levels. Additionally, full-length TrkB accompanied a decreased level less-glycosylated were observed rats following DR, while rats, amplified form TrkB. phosphorylated TrkBY816 stable during regardless feeding. Reduced p75NTR detected regions DR-fed increase was measured These findings shed additional light as modulator revealing its disparate Given importance proBDNF/BDNF circuit-level different brain functions various aspects behavior, it is necessary further elucidate optimal duration applied dietary regimen with regard animal age order achieve most favorable effects.