Prävention des linksventrikulären Remodelings
作者： T. Thum , G. Ertl , J. Bauersachs
DOI: 10.1007/S12181-008-0072-2
关键词:
摘要: Die Umbauprozesse des Herzens nach einem Myokardinfarkt werden als „Remodeling“ bezeichnet, das charakterisiert ist durch Ausdunnung der infarzierten Myokardwand und strukturelle Umgestaltung uberlebenden Myokardanteile mit Myozytenhypertrophie, interstitieller Fibrose sowie Verformung Dilatation Herzkammer. Hemmer Renin-Angiotensin-Aldosteron-Systems vermindern Remodeling verbessern die Prognose bei Patienten eingeschrankter Ventrikelfunktion. Aldosteronantagonisten scheinen daruber hinaus auch fruhe Heilungsprozesse positiv zu beeinflussen. Zellbasierte Therapieansatze haben in ersten Studien positive Einflusse gezeigt, Nachweis anhaltender Effekte auf Herzfunktion, grosen randomisierten steht jedoch noch aus.
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