Bone Histomorphometry and Undecalcified Sections

摘要: Bone histomorphometry is a useful tool to understand the cellular and tissue levels of bone activities correlate clinical symptoms for diagnostic choice remedy. Experience training histomorphometrist, that usually take months fully develop narrow coefficient variation, decide reliability data. Expansion collective histomorphometric data from cohorts demographically matched subjects assists revelation disease mechanisms. Although are limited represent short period surfaces cell focal defined sized biopsy, reviewer’s knowledge understanding on physiology crucial decipher them accurate interpretations. Carefully chosen fluorochrome agents properly administering with known interval aid demonstration temporal spatial relationships surface movement. Estimation erosion depth in conjunction measurement BMU wall thickness demonstrates unit balance. Derivative estimation BMU’s activation frequency formation activity parameters enlarges scope balance examine alterations total mass. Inclusion subject’s medical history observations blood chemistry radiodensitometry completes evaluation exploring explaining symptoms. Histomorphometric before after treatment regimens can facilitate development new drugs specific disease.