Occupation during life and risk of dementia in French elderly community residents

摘要: OBJECTIVE—To determine whether principal occupation during life is a risk factor for incident Alzheimer's disease, vascular dementia, or dementia with parkinsonism. METHODS—This study was carried out from the PAQUID (Personnes Agees QUID) cohort, an epidemiological on normal and pathological aging after 65 years in south west of France. At baseline, 2950 non-demented people living at home were identified re-examined 1, 3, 5, 8, 10 later identical standardised neurological neuropsychological measures. Cox proportional hazards models delayed entry used, taking age as time scale adjusting sex, education, tobacco, wine consumption to estimate ratio (RR) parkinsonism associated occupational category. RESULTS—Of subjects, 393 became demented, whom 251 had 112 27 parkinsonism. The disease not related given occupation. However seemed be increased farmers comparison professionals managerials, particularly among women (RR 7.47; 95%CI, 1.80-31.07). CONCLUSION—The data suggest that does change which seems more influenced by cognitive abilities childhood adolescence than adult life. However, being farmer may increase women; could act way differences health behaviour exposure environmental factors.