Effect of atorvastatin on energy expenditure and skeletal muscle oxidative metabolism at rest and during exercise.

摘要: Statins are associated with adverse effects in skeletal muscle. This study tested the hypothesis that atorvastatin would increase respiratory exchange ratio (RER) at rest and during exercise. Twenty-eight healthy subjects (mean age 52 years) were enrolled a double-blind, placebo-controlled, randomized of (40 mg/day) on whole body energetics over 8 weeks. Ventilatory gas measurements, bicycle ergometry, used to assess muscle oxidative metabolism. Thirteen from each treatment arm completed study. Eight weeks lowered plasma low-density lipoprotein cholesterol concentration but had no effect resting or submaximal energy expenditure, RER, calculated fatty acid oxidation rates. Atorvastatin did not affect maximal exercise oxygen consumption anaerobic threshold. therapy was alterations substrate oxidation, function rest, adults. Clinical Pharmacology & Therapeutics (2008) doi:10.1038/sj.clpt.6100264