Pilot study of high-dose thiotepa and etoposide with autologous bone marrow rescue in children and young adults with recurrent CNS tumors. The Children's Cancer Group.
作者： J L Finlay , S Goldman , M C Wong , M Cairo , J Garvin
DOI: 10.1200/JCO.1996.14.9.2495
关键词:
摘要: PURPOSEThis study was designed to determine the toxicity, radiographic response rate, and outcome following high-dose thiotepa, etoposide, autologous bone marrow rescue (ABMR) for young patients with recurrent malignant brain tumors.METHODSEligibility criteria required adequate renal, hepatic, pulmonary function, no infiltration. Thiotepa 300 mg/m2 etoposide 500 mg/ m2 were infused on 3 consecutive days, 72 hours chemotherapy.RESULTSForty-five high-grade tumors, aged 8 months 36 years (median, years), treated. Seven (16%) died of treatment-related toxicities within 56 days reinfusion. Delayed platelet engraftment occurred in 44% who survived beyond day 56. Of 35 radiographically measurable disease at least 28 ABMR, there two complete responses (CRs) six partial (PRs), an overall (CRs plu...
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