Subgenual Prefrontal Cortex Volumes in Major Depressive Disorder and Schizophrenia: Diagnostic Specificity and Prognostic Implications
作者： William Coryell , Peg Nopoulos , Wayne Drevets , Thomine Wilson , Nancy C. Andreasen
DOI: 10.1176/APPI.AJP.162.9.1706
关键词:
摘要: OBJECTIVE: A variety of findings have implicated the portion anterior cingulate cortex ventral to corpus callosum in pathophysiology familial depressive disorder. There are, as yet, few data address specificity these abnormalities disorders or characterize their stability over time. METHOD: The authors studied 10 subjects who were judged had major disorder with psychotic features, underwent magnetic resonance imaging (MRI) protocols, and participated a longitudinal study recent-onset psychosis. These group-matched schizophrenia well comparison subjects. Volumetric measures made posterior portions subgenual prefrontal for 30 Follow-up scans done an average 4 years after intake available seven disorder, nine schizophrenia, five RESULTS: Volumes left ...
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