作者: Wei-Chun Wu , Hong Ma , Rong-Ai Xie , Li-Jian Gao , Yue Tang
DOI: 10.1111/ECHO.13133
关键词:
摘要: Background This study evaluated the role of two-dimensional speckle tracking echocardiography (2DSTE) for predicting left ventricular (LV) diastolic dysfunction in pacing-induced canine heart failure. Methods Pacing systems were implanted 8 adult mongrel dogs, and continuous rapid right pacing (RVP, 240 beats/min) was maintained 2 weeks. The obtained measurements from 2DSTE included global strain rate during early diastole (SRe) late (SRa) longitudinal (L-SRe, L-SRa), circumferential (C-SRe, C-SRa), radial directions (R-SRe, R-SRa). Changes morphology observed by light microscopy transmission electron at weeks. Results The onset LV with systolic occurred 3 days after RVP initiation. Most imaging indices altered 1 or continued to worsen until failure developed. Light showed myocardial vacuolar degeneration mitochondrial swelling weeks onset. Pearson's correlation analysis revealed that parameters conventional moderate pressure parameters, including (r = 0.58, P < 0.01), L-SRe −0.58, E/L-SRe 0.65, R-SRe 0.53, 0.01). ROC curves these could effectively predict (area under curve: 0.78; 0.84; 0.80; 0.80). Conclusion 2DSTE a sensitive accurate technique be used model.