Re-polarization of immunosuppressive macrophages to tumor-cytotoxic macrophages by repurposed metabolic drugs.

作者: Annemarie Boerma , Toos Daemen , Cesar Oyarce , Shipeng Chen , Ana Vizcaino-Castro

DOI: 10.1080/2162402X.2021.1898753

关键词:

摘要: … drugs to modify immunosuppressive M2-like macrophages into antitumoral M1-like … new platform to test whether drugs clinically available can promote macrophage re-polarization into a …

参考文章(51)
Benedetta C. Sallustio, Ian S. Westley, Raymond G. Morris, Pharmacokinetics of the antianginal agent perhexiline: relationship between metabolic ratio and steady-state dose. British Journal of Clinical Pharmacology. ,vol. 54, pp. 107- 114 ,(2002) , 10.1046/J.1365-2125.2002.01618.X
Luke AJ O’Neill, Silvia Galvan-Penal, Metabolic Reprograming in Macrophage Polarization Frontiers in Immunology. ,vol. 5, pp. 420- 420 ,(2014) , 10.3389/FIMMU.2014.00420
Zheng Tan, Na Xie, Huachun Cui, Douglas R. Moellering, Edward Abraham, Victor J. Thannickal, Gang Liu, Pyruvate Dehydrogenase Kinase 1 Participates in Macrophage Polarization via Regulating Glucose Metabolism Journal of Immunology. ,vol. 194, pp. 6082- 6089 ,(2015) , 10.4049/JIMMUNOL.1402469
Bin-Zhi Qian, Jiufeng Li, Hui Zhang, Takanori Kitamura, Jinghang Zhang, Liam R. Campion, Elizabeth A. Kaiser, Linda A. Snyder, Jeffrey W. Pollard, CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis Nature. ,vol. 475, pp. 222- 225 ,(2011) , 10.1038/NATURE10138
Laura Campbell, Charis R. Saville, Peter J. Murray, Sheena M. Cruickshank, Matthew J. Hardman, Local Arginase 1 Activity Is Required for Cutaneous Wound Healing Journal of Investigative Dermatology. ,vol. 133, pp. 2461- 2470 ,(2013) , 10.1038/JID.2013.164
Divya Vats, Lata Mukundan, Justin I. Odegaard, Lina Zhang, Kristi L. Smith, Christine R. Morel, David R. Greaves, Peter J. Murray, Ajay Chawla, Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation Cell Metabolism. ,vol. 4, pp. 13- 24 ,(2006) , 10.1016/J.CMET.2006.05.011
Tamás Rőszer, María P. Menéndez-Gutiérrez, Marta Cedenilla, Mercedes Ricote, Retinoid X receptors in macrophage biology Trends in Endocrinology & Metabolism. ,vol. 24, pp. 460- 468 ,(2013) , 10.1016/J.TEM.2013.04.004
Alex J. Freemerman, Amy R. Johnson, Gina N. Sacks, J. Justin Milner, Erin L. Kirk, Melissa A. Troester, Andrew N. Macintyre, Pankuri Goraksha-Hicks, Jeffery C. Rathmell, Liza Makowski, Metabolic Reprogramming of Macrophages GLUCOSE TRANSPORTER 1 (GLUT1)-MEDIATED GLUCOSE METABOLISM DRIVES A PROINFLAMMATORY PHENOTYPE Journal of Biological Chemistry. ,vol. 289, pp. 7884- 7896 ,(2014) , 10.1074/JBC.M113.522037
C Cocco, E Di Carlo, S Zupo, S Canale, A Zorzoli, D Ribatti, F Morandi, E Ognio, I Airoldi, Complementary IL-23 and IL-27 anti-tumor activities cause strong inhibition of human follicular and diffuse large B-cell lymphoma growth in vivo Leukemia. ,vol. 26, pp. 1365- 1374 ,(2012) , 10.1038/LEU.2011.363