Prediction of breast and prostate cancer risks in male BRCA1 and BRCA2 mutation carriers using polygenic risk scores

作者: Julie Lecarpentier , Valentina Silvestri , Karoline B Kuchenbaecker , Daniel Barrowdale , Joe Dennis

DOI: 10.1200/JCO.2016.69.4935

关键词:

摘要: PurposeBRCA1/2 mutations increase the risk of breast and prostate cancer in men. Common genetic variants modify risks for female carriers BRCA1/2 mutations. We investigated—for first time to our knowledge—associations common with male implications prediction.Materials MethodsWe genotyped 1,802 from Consortium Investigators Modifiers by using custom Illumina OncoArray. investigated combined effects established susceptibility on constructing weighted polygenic scores (PRSs) published effect estimates as weights.ResultsIn mutations, PRS that was based 88 associated (odds ratio per standard deviation PRS, 1.36; 95% ...

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